Article
Modelling and measuring single cell RNA expression levels find considerable transcriptional differences among phenotypically identical cells.
BMC genomics - 3 Jun 2008
Subkhankulova Tatiana, Gilchrist Michael J, Livesey Frederick J
Abstract excerpt
BACKGROUND: Phenotypically identical cells demonstrate predictable, robust behaviours. However, there is uncertainty as to whether phenotypically identical cells are equally similar at the underlying transcriptional level or if cellular systems are inherently noisy. To answer this question, it is essential to distinguish between technical noise and true variation in transcript levels. A critical issue is the...
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