Article

Glucocorticoid-mediated Aβ and SCG10 upregulation evoke microtubule dysfunction and memory deficits

2018-05-14

Abstract excerpt

We investigated glucocorticoid, a major risk factor of Alzheimer’s disease, promoted microtubule instability that culminates in memory deficits. Mice group exposed to corticosteroid had reduced trafficking of AMPAR1/2 and mitochondria into the synapse due to microtubule destabilization, which finally impaired cognitive function. Furthermore, cortisol reduced microtubule stability through the mitochondria glucocort...

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Literature Corpus work: 20c5199e-4b85-5b99-a26f-42671382f28c
DOI: 10.1101/322610

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