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Article

Glucocorticoid impairs mitochondrial quality control in neurons

17 Feb 2021

Abstract excerpt

Neurons are particularly vulnerable to mitochondrial dysfunction due to high energy demand and an inability to proliferate. Therefore, dysfunctional mitochondria cause various neuropathologies. Mitochondrial damage induces maintenance pathways to repair or eliminate damaged organelles. This mitochondrial quality control (MQC) system maintains appropriate morphology, localization, and removal/replacement of...

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PMID: 33609641
DOI: 10.1016/j.nbd.2021.105301

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