Article
Andrographolide sulfonate improves Alzheimer-associated phenotypes and mitochondrial dysfunction in APP/PS1 transgenic mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jan 2018
Geng Ji, Liu Wen, Xiong Yuyun, Ding Hongqun, Jiang Chunhong, Yang Xiaoling, Li Xiang, Elgehama Ahmed, Sun Yang, Xu Qiang, Guo Wenjie, Gao Jing
Abstract excerpt
Alzheimer's disease is a neurodegenerative disorder with Amyloid-β plaques onset, synaptic damage, and cognitive decline. Aβ deposits cause pathological events including oxidative stress, mitochondrial dysfunction, and neuron death. In this study, APPswe/PSENΔ9 double transgenic mice model was used to imitate Alzheimer's disease and the effect and possible mechanism of Andrographolide sulfonate were examined....
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