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Article

Rab11a and HSP90 Regulate Recycling of Extracellular α-Synuclein

4 Feb 2009

Abstract excerpt

Growing evidence suggests that extracellular alpha-synuclein (eSNCA) may play an important role in the pathogenesis of Parkinson's disease (PD) and related synucleinopathies by producing neurotoxicity directly or via activation of glia. However, the mechanisms involved in the trafficking of eSNCA in neurons and/or glia remain unclear. Here, we demonstrated that eSNCA could be resecreted out of neurons via a...

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Identifiers

PMID: 19193894
DOI: 10.1523/jneurosci.6202-08.2009

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