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Article

Subchronic glucocorticoid receptor inhibition rescues early episodic memory and synaptic plasticity deficits in a mouse model of Alzheimer's disease.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jun 2015

Lanté Fabien, Chafai Magda, Raymond Elisabeth Fabienne, Pereira Ana Rita Salgueiro, Mouska Xavier, Kootar Scherazad, Barik Jacques, Bethus Ingrid, Marie Hélène

Abstract excerpt

The early phase of Alzheimer's disease (AD) is characterized by hippocampus-dependent memory deficits and impaired synaptic plasticity. Increasing evidence suggests that stress and dysregulation of the hypothalamo-pituitary-adrenal (HPA) axis, marked by the elevated circulating glucocorticoids, a...

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Identifiers

PMID: 25622751
DOI: 10.1038/npp.2015.25
PMCID: PMC4915261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25622751-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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