Article

GRK5 deficiency in the hippocampus leads to Alzheimer’s Disease-like phenotypes via the abnormal microglia alterations

2022-08-11

Abstract excerpt

<title>Abstract</title> <p>GRK5 is a member of the G protein-coupled receptors (GPCRs) kinase family and is closely associated with Alzheimer's disease (AD). However, the biological function of GRK5 in the brain and the causal link between GRK5 deficiency and AD-like pathology is unknown. Here, we show that GRK5 is reduced in the AD mouse brain, and mice with reduced GRK5 in the hippocampus induce cognitive impai...

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Literature Corpus work: 0bfa1d17-fb24-5d01-ac34-4fd48812ebc4
DOI: 10.21203/rs.3.rs-1927604/v1

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