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Article

Behavioral stress causes mitochondrial dysfunction via ABAD up-regulation and aggravates plaque pathology in the brain of a mouse model of Alzheimer disease.

Free radical biology & medicine - 1 Jun 2011

Seo Ji-Seon, Lee Kang-Woo, Kim Tae-Kyung, Baek In-Sun, Im Joo-Young, Han Pyung-Lim

Abstract excerpt

Basic and clinical studies have reported that behavioral stress worsens the pathology of Alzheimer disease (AD), but the underlying mechanism has not been clearly understood. In this study, we determined the mechanism by which behavioral stress affects the pathogenesis of AD using Tg-APPswe/PS1dE9 mice, a murine model of AD. Tg-APPswe/PS1dE9 mice that were restrained for 2h daily for 16 consecutive days...

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Source

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PMID: 21382475
DOI: 10.1016/j.freeradbiomed.2011.02.035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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