Article

Injury induced renal fibrosis promotes cystogenesis and cyst growth in adult mice with autosomal dominant polycystic kidney disease

2023-10-10

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is a life-long disease and caused by mutations in PKD1 or PKD2 gene. Fibrosis is a hallmark of chronic kidney disease and is positively correlated with renal cyst growth, however the role of fibrosis in ADPKD is still controversial. In this study, we established renal fibrosis by toxic or surgical injuries in adult mice, and Pkd gene was inactivated at differ...

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Literature Corpus work: 20910956-e1b2-5561-9d0f-6dfcdcef88d6
DOI: 10.1101/2023.10.08.561382

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