Article
PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype.
Nature communications - 3 Dec 2015
Duan Shunlei, Yuan Guohong, Liu Xiaomeng, Ren Ruotong, Li Jingyi, Zhang Weizhou, Wu Jun, Xu Xiuling, Fu Lina, Li Ying, Yang Jiping, Zhang Weiqi, Bai Ruijun, Yi Fei, Suzuki Keiichiro, Gao Hua, Esteban Concepcion Rodriguez, Zhang Chuanbao, Izpisua Belmonte Juan Carlos, Chen Zhiguo, Wang Xiaomin, Jiang Tao, Qu Jing, Tang Fuchou, Liu Guang-Hui
Abstract excerpt
PTEN is a tumour suppressor frequently mutated in many types of cancers. Here we show that targeted disruption of PTEN leads to neoplastic transformation of human neural stem cells (NSCs), but not mesenchymal stem cells. PTEN-deficient NSCs display neoplasm-associated metabolic and gene expression profiles and generate intracranial tumours in immunodeficient mice. PTEN is localized to the nucleus in NSCs, binds...
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