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Article

<i>Pten</i> Haploinsufficiency Accelerates Formation of High-Grade Astrocytomas

1 May 2008

Abstract excerpt

We previously reported that central nervous system (CNS) inactivation of Nf1 and p53 tumor suppressor genes in mice results in the development of low-grade to high-grade progressive astrocytomas. When the tumors achieve high grade, they are frequently accompanied by Akt activation, reminiscent of the frequent association of PTEN mutations in human high-grade glioma. In the present study, we introduced CNS...

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PMID: 18451155
DOI: 10.1158/0008-5472.can-07-6867

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