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Article

Activated KRAS reprograms neural progenitor cells to glioma stem cell‑like phenotype.

International journal of oncology - 1 Jul 2023

Qin Zixi, Liang Weiye, Zhang Zixuan, Li Peiwen, Wang Tianyu, Chen Qianyu, Guo Baoyin, Zhong Ying, Kang Hui, Wang Lihui

Abstract excerpt

Glioma is the most common primary brain tumor. Glioma stem cells (GSCs) are the origin of gliomagenesis and may develop from normal neural progenitor cells (NPCs). However, how neoplastic transformation occurs in normal NPCs and the role of the Ras/Raf/MAPK pathway in NPC transformation is unclear. The present study generated NPCs from human embryonic stem cells (ESCs) carrying gene alterations in the...

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Identifiers

PMID: 37326110
DOI: 10.3892/ijo.2023.5536
PMCID: PMC10552691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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