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Article

Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma.

PloS one - 26 May 2010

Castellino Robert C, Barwick Benjamin G, Schniederjan Matthew, Buss Meghan C, Becher Oren, Hambardzumyan Dolores, Macdonald Tobey J, Brat Daniel J, Durden Donald L

Abstract excerpt

BACKGROUND: Recent publications have described an important role for cross talk between PI-3 kinase and sonic hedgehog signaling pathways in the pathogenesis of medulloblastoma. METHODOLOGY/PRINCIPAL FINDINGS: We crossed mice with constitutive activation of Smoothened, SmoA1, with Pten deficient mice. Both constitutive and conditional Pten deficiency doubled the incidence of mice with symptoms of medulloblastoma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neovascularization, Pathologic

Share to Phosphatidylinositol 3-Kinases

Share to PTEN Phosphohydrolase

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Source

Open in PubMed Open full text

Identifiers

PMID: 20520772
DOI: 10.1371/journal.pone.0010849
PMCID: PMC2877103

Genes

PTEN

Provenance

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