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Human induced pluripotent stem cell engineering establishes a humanized mouse platform for pediatric low-grade glioma modeling

19 Aug 2022

Abstract excerpt

A major obstacle to identifying improved treatments for pediatric low-grade brain tumors (gliomas) is the inability to reproducibly generate human xenografts. To surmount this barrier, we leveraged human induced pluripotent stem cell (hiPSC) engineering to generate low-grade gliomas (LGGs) harboring the two most common pediatric pilocytic astrocytoma-associated molecular alterations, NF1 loss and KIAA1549:BRAF...

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PMID: 35986378
DOI: 10.1186/s40478-022-01428-2

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