Article

Role of Mitochondrial Dynamics in Microglial Activation and Metabolic Switch

2021-01-06

Abstract excerpt

Microglia act as sensors of injury in the brain, favouring its homeostasis. Their activation and polarization towards a pro-inflammatory phenotype are associated to injury and disease. These processes are linked to a metabolic reprogramming of the cells, characterized by high rates of glycolysis and suppressed oxidative phosphorylation. This metabolic switch can be reproduced in vitro by microglial stimulation wit...

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Literature Corpus work: 2066a314-26dd-5709-9cae-12759e47ab28
DOI: 10.21203/rs.3.rs-134161/v1

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