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M1 Microglia Induced Neuronal Injury on Ischemic Stroke via Mitochondrial Crosstalk between Microglia and Neurons.

Oxidative medicine and cellular longevity - 1 Jan 2022

Liu Wei, Qi Zitong, Li Wanmeng, Liang Jia, Zhao Liang, Shi Yijie

Abstract excerpt

Among the middle-aged and senile populations, ischemic stroke (IS) is a frequently occurring acute condition of the cerebrovascular system. Traditionally, it is recognized that when stroke occurs, microglia are activated into M1 phenotype and release cytotoxic cytokines, reactive oxygen species, proteases, and other factors, thus exacerbating the injury by further destroying or killing nearby neurons. In the...

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PMID: 36478988
DOI: 10.1155/2022/4335272
PMCID: PMC9722306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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