Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Does polygenic risk for substance-related traits predict ages of onset and progression of symptoms?

Addiction (Abingdon, England) - 1 Sept 2023

Kranzler Henry R, Feinn Richard, Xu Heng, Ho Brendan L, Saini Divya, Nicastro Olivia R, Jacoby Anya, Toikumo Sylvanus, Gelernter Joel, Hartwell Emily E, Kember Rachel L

Abstract excerpt

BACKGROUND AND AIMS: Genetic risk can influence disease progression. We measured the impact of genetic risk for substance use disorders (SUDs) on substance use onset and progression of symptoms. DESIGN, SETTING, PARTICIPANTS: Using findings from genome-wide association studies (GWASs) of alcohol use disorder (AUD), opioid use disorder (OUD) and smoking trajectory (SMK) as discovery samples, we calculated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking
Share to Alcoholism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ethanol

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Multifactorial Inheritance

Share to Risk Factors

Share to Substance-Related Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 37069489
DOI: 10.1111/add.16210
PMCID: PMC10525011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Does polygenic risk for substance-related traits predict ages of onset and progression of symptoms?PMID 37069489Read ↗

Polygenic Risk for Substance-Related Traits Predicts Substance Use Onset and Progression: Sex and Population Group DifferencesSemantic proximity Read ↗

Polygenic Scores Predict the Development of Alcohol and Nicotine Use Problems from Adolescence through Young AdulthoodSemantic proximity Read ↗

Trajectories of genetic risk across dimensions of alcohol use behaviors.Semantic proximity Read ↗

High Polygenic Risk Scores Are Associated With Early Age of Onset of Alcohol Use Disorder in Adolescents and Young Adults at RiskSemantic proximity Read ↗

Using polygenic scores for identifying individuals at increased risk of substance use disorders in clinical and population samplesSemantic proximity Read ↗

Clinical, Environmental, and Genetic Risk Factors for Substance Use Disorders: Characterizing Combined Effects across Multiple CohortsSemantic proximity Read ↗

Polygenic Prediction of Substance Use Disorders in Clinical and Population SamplesSemantic proximity Read ↗

Exploring the relationship between polygenic risk for cannabis use, peer cannabis use and the longitudinal course of cannabis involvement.Semantic proximity Read ↗

Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations.Semantic proximity Read ↗

Toward Clinical Implementation of Polygenic Scores for Substance Use Disorders: A Multi-Ancestry StudySemantic proximity Read ↗

Associations of childhood adversity and substance use disorder polygenic scores with disorder severity and diagnostic criteria.Semantic proximity Read ↗

Phenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.