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Article

Associations of childhood adversity and substance use disorder polygenic scores with disorder severity and diagnostic criteria.

Psychological medicine - 2 May 2025

SooHoo Jackson F, Davis Christal N, Han Angela, Jinwala Zeal, Gelernter Joel, Feinn Richard, Kranzler Henry R

Abstract excerpt

BACKGROUND: Genetic and environmental factors, including adverse childhood experiences (ACEs), contribute to substance use disorders (SUDs). However, the interactions between these factors are poorly understood. METHODS: We examined associations between SUD polygenic scores (PGSs), ACEs, and the initiation of use and severity of alcohol (AUD), opioid use disorder (OUD), and cannabis use disorder (CanUD) in 10,275...

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Identifiers

PMID: 40314172
DOI: 10.1017/S0033291725001163
PMCID: PMC12094658

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