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Article

CD44ICD promotes breast cancer stemness via PFKFB4-mediated glucose metabolism

1 Jan 2018

Abstract excerpt

CD44 is a single-pass cell surface glycoprotein that is distinguished as the first molecule used to identify cancer stem cells in solid tumors based on its expression. In this regard, the CD44 high cell population demonstrates not only the ability to regenerate a heterogeneous tumor, but also the ability to self-regenerate when transplanted into immune-deficient mice. However, the exact role of CD44 in cancer...

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PMID: 30613295
DOI: 10.7150/thno.28721

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