Article
SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity.
Cell reports - 21 Feb 2017
Ioris Rafael M, Galié Mirco, Ramadori Giorgio, Anderson Jason G, Charollais Anne, Konstantinidou Georgia, Brenachot Xavier, Aras Ebru, Goga Algera, Ceglia Nicholas, Sebastián Carlos, Martinvalet Denis, Mostoslavsky Raul, Baldi Pierre, Coppari Roberto
Abstract excerpt
Cancer stem cells (CSCs) have high tumorigenic capacity. Here, we show that stem-like traits of specific human cancer cells are reduced by overexpression of the histone deacetylase sirtuin 6 (SIRT6). SIRT6-sensitive cancer cells bear mutations that activate phosphatidylinositol-3-kinase (PI3K) signaling, and overexpression of SIRT6 reduces growth, progression, and grade of breast cancer in a mouse model with PI3K...
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