Article

De novo haplotype reconstruction in viral quasispecies using paired-end read guided path finding

2018-01-28

Abstract excerpt

<h4>Motivation</h4> RNA virus populations contain closely related but different viral strains infecting an individual host. As the selection acts on clouds of mutants rather than single sequences, these viruses have abilities to escape host immune responses or develop drug resistance. Reconstruction of the viral haplotypes is a fundamental step to characterize the virus population, predict their viral phenotypes,...

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Literature Corpus work: 200165c8-1ea1-5b1c-ab30-b410211be9a5
DOI: 10.1101/254987

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