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Article

Evaluation of haplotype callers for next-generation sequencing of viruses.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Aug 2020

Eliseev Anton, Gibson Keylie M, Avdeyev Pavel, Novik Dmitry, Bendall Matthew L, Pérez-Losada Marcos, Alexeev Nikita, Crandall Keith A

Abstract excerpt

Currently, the standard practice for assembling next-generation sequencing (NGS) reads of viral genomes is to summarize thousands of individual short reads into a single consensus sequence, thus confounding useful intra-host diversity information for molecular phylodynamic inference. It is hypothesized that a few viral strains may dominate the intra-host genetic diversity with a variety of lower frequency strains...

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Identifiers

PMID: 32151775
DOI: 10.1016/j.meegid.2020.104277
PMCID: PMC7293574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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