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Article

Viral quasispecies assembly via maximal clique enumeration.

PLoS computational biology - 1 Mar 2014

Töpfer Armin, Marschall Tobias, Bull Rowena A, Luciani Fabio, Schönhuth Alexander, Beerenwinkel Niko

Abstract excerpt

Virus populations can display high genetic diversity within individual hosts. The intra-host collection of viral haplotypes, called viral quasispecies, is an important determinant of virulence, pathogenesis, and treatment outcome. We present HaploClique, a computational approach to reconstruct the structure of a viral quasispecies from next-generation sequencing data as obtained from bulk sequencing of mixed...

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Identifiers

PMID: 24675810
DOI: 10.1371/journal.pcbi.1003515
PMCID: PMC3967922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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