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Benchmarking of viral haplotype reconstruction programmes: an overview of the capacities and limitations of currently available programmes.

Briefings in bioinformatics - 1 May 2014

Schirmer Melanie, Sloan William T, Quince Christopher

Abstract excerpt

Viral haplotype reconstruction from a set of observed reads is one of the most challenging problems in bioinformatics today. Next-generation sequencing technologies enable us to detect single-nucleotide polymorphisms (SNPs) of haplotypes-even if the haplotypes appear at low frequencies. However, there are two major problems. First, we need to distinguish real SNPs from sequencing errors. Second, we need to...

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PMID: 23257116
DOI: 10.1093/bib/bbs081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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