Article
Benchmarking of viral haplotype reconstruction programmes: an overview of the capacities and limitations of currently available programmes.
Briefings in bioinformatics - 1 May 2014
Schirmer Melanie, Sloan William T, Quince Christopher
Abstract excerpt
Viral haplotype reconstruction from a set of observed reads is one of the most challenging problems in bioinformatics today. Next-generation sequencing technologies enable us to detect single-nucleotide polymorphisms (SNPs) of haplotypes-even if the haplotypes appear at low frequencies. However, there are two major problems. First, we need to distinguish real SNPs from sequencing errors. Second, we need to...
Topics
- Animals
- Computational Biology
- Computer Simulation
- Databases, Nucleic Acid
- Evolution, Molecular
- Foot-and-Mouth Disease Virus
- HIV-1
- Haplotypes
- High-Throughput Nucleotide Sequencing
- Humans