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Article

Phenotypic diversity of T cells in human primary and metastatic brain tumors revealed by multiomic interrogation

22 May 2023

Abstract excerpt

Abstract The immune-specialized environment of the healthy brain is tightly regulated to prevent excessive neuroinflammation. However, after cancer development, a tissue-specific conflict between brain-preserving immune suppression and tumor-directed immune activation may ensue. To interrogate potential roles of T cells in this process, we profiled these cells from individuals with primary or metastatic brain...

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PMID: 37217652
DOI: 10.1038/s43018-023-00566-3

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