Article

Z-DNA formation in promoters conserved between human and mouse are associated with increased transcription initiation rates

2024-03-22

Abstract excerpt

<title>Abstract</title> <p>A long-standing question concerns the role of Z-DNA in transcription. Here we use a deep learning approach DeepZ that predicts Z-flipons based on DNA sequence, structural properties of nucleotides and omics data. We examined Z-flipons that are conserved between human and mouse genomes after generating whole-genome Z-flipon map and then validated them by orthogonal approaches based on hi...

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Literature Corpus work: 32843a10-d732-5797-81b2-d044e0eb9418
DOI: 10.21203/rs.3.rs-4018512/v1

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