Article

The effect of antibiotic selection on collateral effects and evolvability of uropathogenic <i>Escherichia coli</i>

2023-11-14

Abstract excerpt

Trimethoprim is recommended as a first-line treatment of urinary tract infections (UTIs) in the UK. In 2018, 31.4% of Escherichia coli isolated from UTIs in England were trimethoprim resistant, leading to overreliance on other first and second-line antibiotics. Here, we assessed whether prior selection with trimethoprim results in collateral effects to other antibiotics recommended for the treatment of UTIs. As c...

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Literature Corpus work: 1fb823da-6770-5f47-952d-c4fd58d5406a
DOI: 10.1101/2023.11.14.567005

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