Article

Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen <i>Pseudomonas aeruginosa</i>

2019-03-09

Abstract excerpt

Evolution is at the core of the impending antibiotic crisis. Sustainable therapy must thus account for the adaptive potential of pathogens. One option is to exploit evolutionary trade-offs, like collateral sensitivity, where evolved resistance to one antibiotic causes hypersensitivity to another one. To date, the evolutionary stability and thus clinical utility of this trade-off is unclear. We performed a critical...

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Literature Corpus work: a354adc3-53b3-50f1-a036-a979f433403e
DOI: 10.1101/570663

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