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SP1-mediated up-regulation of lncRNA TUG1 underlines an oncogenic property in colorectal cancer

4 May 2022

Abstract excerpt

The long non-coding RNA (lncRNA) taurine up-regulated gene 1 (TUG1) acts as tumor-promoting factor in colorectal cancer (CRC). We aimed to elucidate the mechanism by which the transcription factor specificity protein 1 (SP1) regulates TUG1 and microRNAs (miRs)/mRNAs in the context of CRC, which has not been fully studied before. Expression patterns of TUG1 and SP1 were determined in clinical CRC samples and...

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PMID: 35508523
DOI: 10.1038/s41419-022-04805-w

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