Article

Endocrine disruption of early uterine differentiation causes adenocarcinoma mediated by Wnt/β-catenin- and PI3K/AKT signaling

2022-11-18

Abstract excerpt

Developmental exposure to non-mutagenic environmental factors can contribute to cancer risk, but the underlying mechanisms are not understood. We used a mouse model of endometrial adenocarcinoma that results from brief developmental exposure to an estrogenic chemical, diethylstilbestrol (DES), to determine causative factors. Single cell RNA sequencing and spatial transcriptomics of adult uteri revealed new markers...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d52c94f2-a654-547e-9fdd-2ae1cecb40c5
DOI: 10.1101/2022.11.18.517135

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Endocrine disruption of early uterine differentiation causes adenocarcinoma mediated by Wnt/β-catenin- and PI3K/AKT signalingDOI 10.1101/2022.11.18.517135Read

Developmental estrogen exposure in mice disrupts uterine epithelial cell differentiation and causes adenocarcinoma via Wnt/β-catenin and PI3K/AKT signalingSemantic proximity Read

Neonatal diethylstilbestrol exposure disrupts uterine epithelial apical-basal polarity and partial EMT stateSemantic proximity Read

Diethylstilbestrol exposure in utero: A paradigm for mechanisms leading to adult diseaseSemantic proximity Read

Epigenomic reprogramming of the developing reproductive tract and disease susceptibility in adulthoodSemantic proximity Read

SIX1 Regulates Aberrant Endometrial Epithelial Cell Differentiation and Cancer Latency Following Developmental Estrogenic Chemical ExposureSemantic proximity Read

Developmental exposure to diethylstilbestrol alters uterine gene expression that may be associated with uterine neoplasia later in lifeSemantic proximity Read

Environmental Exposure, DNA Methylation, and Gene RegulationSemantic proximity Read

The epigenomics of cancer.Semantic proximity Read

Epigenetic Modulation of Inflammatory Pathways in Myometrial Stem Cells and Risk of Uterine FibroidsSemantic proximity Read

Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesisSemantic proximity Read

Early Life Adverse Environmental Exposures Increase the Risk of Uterine Fibroid Development: Role of Epigenetic RegulationSemantic proximity Read

Cells expressing PAX8 are the main source of homeostatic regeneration of adult mouse endometrial epithelium and give rise to serous endometrial carcinomaSemantic proximity Read