Article

Structural basis for constitutive activation of oncogenic gp130 mutants in human inflammatory hepatocellular adenomas

2025-11-12

Abstract excerpt

Inflammatory hepatocellular adenomas (IHCAs) are benign liver tumors primarily driven by somatic mutations in the gp130 receptor, resulting in its constitutive activation. To uncover the structural mechanisms underlying this activation, we employed cryo-electron microscopy and mutagenesis to study five representative IHCAs-associated gp130 mutants and two engineered mutants with ligand-independent activity. Most m...

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Literature Corpus work: 1fac5ee1-3416-5481-9913-a95d812cd6e8
DOI: 10.1101/2025.11.11.685192

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