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Article

Molecular Mechanisms of KIT Receptor Dimerization and Oncogenic Activation Revealed by Multiscale Simulations.

Journal of chemical information and modeling - 13 Jul 2026

Chiariello Maria Gabriella, Biswas Akash Deep, Gratteri Carmen, Prandi Ingrid Guarnetti, Marrink Siewert-Jan, Beccari Andrea, Talarico Carmine

Abstract excerpt

The receptor tyrosine kinase KIT is essential for cell proliferation and differentiation, and its aberrant activation contributes to cancers such as acute myeloid leukemia and gastrointestinal stromal tumors. KIT activation normally requires stem cell factor (SCF)-induced dimerization, whereas oncogenic mutations can drive ligand-independent signaling. Here, we employ multiscale molecular dynamics simulations...

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Share to KIT gene
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-kit

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Identifiers

PMID: 42380068
DOI: 10.1021/acs.jcim.6c00160
PMCID: PMC13370856

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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Molecular Mechanisms of KIT Receptor Dimerization and Oncogenic Activation Revealed by Multiscale Simulations.PMID 42380068Read ↗

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