Article
Kinase regulation by hydrophobic spine assembly in cancer.
Molecular and cellular biology - 1 Jan 2015
Hu Jiancheng, Ahuja Lalima G, Meharena Hiruy S, Kannan Natarajan, Kornev Alexandr P, Taylor Susan S, Shaw Andrey S
Abstract excerpt
A new model of kinase regulation based on the assembly of hydrophobic spines has been proposed. Changes in their positions can explain the mechanism of kinase activation. Here, we examined mutations in human cancer for clues about the regulation of the hydrophobic spines by focusing initially on mutations to Phe. We identified a selected number of Phe mutations in a small group of kinases that included BRAF,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.