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Article

Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas.

The Journal of experimental medicine - 4 Jul 2011

Pilati Camilla, Amessou Mohamed, Bihl Michel P, Balabaud Charles, Nhieu Jeanne Tran Van, Paradis Valérie, Nault Jean Charles, Izard Tina, Bioulac-Sage Paulette, Couchy Gabrielle, Poussin Karine, Zucman-Rossi Jessica

Abstract excerpt

Inflammatory hepatocellular adenomas (IHCAs) are benign liver tumors. 60% of these tumors have IL-6 signal transducer (IL6ST; gp130) mutations that activate interleukin 6 (IL-6) signaling. Here, we report that 12% of IHCA subsets lacking IL6ST mutations harbor somatic signal transducer and activa...

Read the complete abstract on PubMed

Topics

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Share to Active Transport, Cell Nucleus
Share to Adenoma, Liver Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokine Receptor gp130

Share to Mutant Proteins

Share to Protein Structure, Quaternary

Share to src-Family Kinases

Share to STAT3 Transcription Factor

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Source

Open in PubMed Open full text

Identifiers

PMID: 21690253
DOI: 10.1084/jem.20110283
PMCID: PMC3135371

Genes

STAT3
JAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21690253-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas.PMID 21690253Read ↗

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