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Article

Intracellular signaling prevents effective blockade of oncogenic gp130 mutants by neutralizing antibodies.

Cell communication and signaling : CCS - 10 Mar 2014

Rinis Natalie, Küster Andrea, Schmitz-Van de Leur Hildegard, Mohr Anne, Müller-Newen Gerhard

Abstract excerpt

BACKGROUND: Short in-frame deletions in the second extracellular domain of the cytokine receptor gp130 are the leading cause of inflammatory hepatocellular adenomas (IHCAs). The deletions render gp130 constitutively active. In this study we investigate the intracellular signaling potential of one...

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Share to Antibodies, Neutralizing
Share to Cytokine Receptor gp130
Share to Endocytosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycosylation

Share to Golgi Apparatus

Share to MAP Kinase Signaling System

Share to STAT3 Transcription Factor

Share to Suppressor of Cytokine Signaling Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24612692
DOI: 10.1186/1478-811X-12-14
PMCID: PMC4007646

Genes

SOCS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24612692-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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