Article
Blockade of de novo pyrimidine biosynthesis triggers autophagic degradation of oncoprotein FLT3-ITD in acute myeloid leukemia.
Oncogene - 1 Nov 2023
Ma Hui, Cui Jiayan, Liu Zehui, Fang Wenqing, Lu Sisi, Cao Shuying, Zhang Yuanyuan, Chen Ji-An, Lu Lixue, Xie Qiong, Wang Yonghui, Huang Ying, Li Kongfei, Tong Hongyan, Huang Jin, Lu Weiqiang
Abstract excerpt
The internal tandem duplication of the FMS-like tyrosine kinase 3 (FLT3-ITD) is one of the most frequent genetic alterations in acute myeloid leukemia (AML). Limited and transient clinical benefit of FLT3 kinase inhibitors (FLT3i) emphasizes the need for alternative therapeutic options for this subset of myeloid malignancies. Herein, we showed that FLT3-ITD mutant (FLT3-ITD+) AML cells were susceptible toward...
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