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Article

Adaptive antibody diversification through N -linked glycosylation of the immunoglobulin variable region

5 Feb 2018

Abstract excerpt

Significance Structural variation of antibodies is generally defined in terms of amino acid composition, neglecting posttranslational modifications such as N -linked glycosylation. Little is known about the role of the glycans that are present in about 15% of variable domains. However, recent studies suggest that variable domain glycans exhibit distinct patterns according to (patho)physiological conditions, and...

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PMID: 29432186
DOI: 10.1073/pnas.1711720115

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