Article
Diversification and selection mechanisms for the production of protein repertoires: lessons from the immune system.
Applied biochemistry and biotechnology - 1 Jan 2000
Neuberger M S, Sale J E, Cumbers S J, Jolly C J, Bemark M P, Ehrenstein M R, Lanoue A, Brüggemann M, Batista F D, Davies S L, Williams G T
Abstract excerpt
The physiological mechanism for producing antigen-specific antibodies is based on a two-phase neo-Darwinian process: the first phase consists of diversity generation (formation of the repertoire), and the second phase is antigen-mediated selection. In this article, we consider how the natural immunoglobulin gene-diversification processes can be exploited both in vivo and in vitro in order to allow the generation...
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