Article

An engineered IdeS variant with enhanced activity and performance for IgG degradation

2026-07-01

Abstract excerpt

IgG-degrading enzymes have emerged as innovative therapeutic agents for treating conditions driven by pathogenic antibodies. Here, we used structure-guided rational design to engineer IdeS M33 , a double mutant (K167R/D226E) of the IgG-specific bacterial protease IdeS from Streptococcus pyogenes , with improved catalytic efficiency. Biolayer interferometry revealed a fourfold increase in binding affinity relativ...

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Literature Corpus work: a6721f15-fdc8-5fee-aa05-49483a1675ae
DOI: 10.64898/2026.06.26.734701

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