Article

Chemical mutagenesis for the modulation and study of protein function and dysfunction within Alzheimer's disease

2020-01-01

Abstract excerpt

Chemical mutagenesis is defined as the post-expression interconversion of amino-acid (AA) sidechains. This approach enabled the first ever point-mutations in proteins and has seen a resurgence of interest over the last two decades. This thesis reports on two disparate applications of chemical mutagenesis within the context of Alzheimer's disease (AD). First, exploring the capabilities of utilizing chemical mutagen...

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Literature Corpus work: d3755135-7abf-5f45-b730-9f5d1a6c8eee
DOI: 10.17863/cam.68392

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