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Article

Cysteine-reactive mitigators of small vessel disease-related NOTCH3 mutants.

Scientific reports - 20 Mar 2026

Cartee Naw May Pearl, Zhang Xiaojie, Lee Soo Jung, Wang Michael M

Abstract excerpt

Pathogenic alterations in NOTCH3 cause CADASIL, an accelerated and currently untreatable form of cerebrovascular disease. CADASIL mutant NOTCH3, which frequently harbors abnormalities in EGF repeat cysteine number, adopt disulfide dependent abnormal conformations. To seek potential strategies to mitigate the impact of CADASIL mutations on NOTCH3, we investigated whether cysteine-targeting compounds may affect...

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Share to CADASIL
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41862552
DOI: 10.1038/s41598-026-45103-1
PMCID: PMC13144312

Genes

NOTCH3
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Research trail→

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Cysteine-reactive mitigators of small vessel disease-related NOTCH3 mutants.PMID 41862552Read ↗

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