Article

Quantifying E2F1 protein dynamics in single cells

2019-05-10

Abstract excerpt

The Rb/E2F pathway plays a central role in regulating cell-fate decisions and cell-cycle progression. The E2F1 protein, a major effector of the pathway, is regulated via a combination of transcriptional, translational and posttranslational constraints. Elucidating the regulation and impact of the Rb/E2F pathway requires direct measurement of E2F1 dynamics in single cells. To this end, we have engineered fluorescen...

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Literature Corpus work: 1f7de8fe-9f72-5280-8e81-96b2eb2ff88e
DOI: 10.1101/634956

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