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Article

Evolving intricacies and implications of E2F1 regulation

28 Mar 2003

Abstract excerpt

E2F transcription factors may play a pivotal role in the transcriptional regulation of several cellular processes far beyond the originally described cell cycle and proliferation. Among the six E2F family members, only E2F1 is noted for its role in apoptosis. The pocket protein family members Rb, p107, and p130 act as the main regulators of E2F activity. Nonetheless, in recent years other protein-protein...

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PMID: 12665469
DOI: 10.1096/fj.02-0431rev

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