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Integrin β1/FAK/SRC signal pathway is involved in autism spectrum disorder inTspan7knockout rats

20 Dec 2022

Abstract excerpt

knockout rats exhibited ASD-like and ID-like behavioral phenotypes, brain structure alterations including decreased hippocampal and cortical volume, and related pathological changes including reduced hippocampal neurons number, neuronal complexity, dendritic spines, and synapse-associated proteins. Then, we found that TSPAN7 deletion interrupted the integrin β1/FAK/SRC signal pathway that was followed by the...

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PMID: 36625203
DOI: 10.26508/lsa.202201616

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