Article

P2Y2 purinergic receptor and DNA sensor cGAS dictate ionizing radiation-mediated proinflammatory macrophage activation

2024-12-22

Abstract excerpt

The reprogramming of tumor-associated macrophages (TAMs) by radiotherapy is associated with cancer patient’s response and sensitization to immune checkpoint blockade, but the molecular mechanisms involved remain largely unknown. Here, we show that following ionizing radiation (IR), macrophages accumulate single and double strand-DNA breaks and fragmented mitochondria in their cytosol, and stabilize the DNA sensor...

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Identifiers and source

Literature Corpus work: 1f508598-db19-57e0-9d53-7896b2983122
DOI: 10.1101/2024.12.19.629560

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