Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired Integrated Stress Response and Mitochondrial Integrity Modulate Genotoxic Stress Impact and Lower the Threshold for Immune Signalling

20 Mar 2023

Abstract excerpt

Mitochondria-nucleus communication during stress dictates cellular fate with consequences on the etiopathology of multiple age-related diseases. Impaired mitochondrial quality control through loss of function of the mitochondrial protease HtrA2 associates with accumulation of damaged mitochondria and triggers the integrated stress response, implicating the transcription factor CHOP. Here we have employed a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Endoplasmic Reticulum Stress and Disease
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36982965
DOI: 10.3390/ijms24065891

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired Integrated Stress Response and Mitochondrial Integrity Modulate Genotoxic Stress Impact and Lower the Threshold for Immune SignallingPMID 36982965Read ↗

DNA Damage Response and Metabolic Reprogramming in Health and Disease.Semantic proximity Read ↗

Mitochondrial DNA-triggered innate immune response: mechanisms and diseasesSemantic proximity Read ↗

Integrating the DNA damage and protein stress responses during cancer development and treatment.Semantic proximity Read ↗

When Endoplasmic Reticulum Proteostasis Meets the DNA Damage ResponseSemantic proximity Read ↗

G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response ProcessesSemantic proximity Read ↗

Emerging mitochondrial signaling mechanisms in cardio-oncology: beyond oxidative stressSemantic proximity Read ↗

A Complex Scenario and Underestimated Challenge: The Tumor Microenvironment, ER Stress, and Cancer TreatmentSemantic proximity Read ↗

DNA damage invokes mitophagy through a pathway involving Spata18Semantic proximity Read ↗

DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunitySemantic proximity Read ↗

Cytosolic Self-DNA—A Potential Source of Chronic Inflammation in AgingSemantic proximity Read ↗

The Intersection of DNA Damage Response and Ferroptosis—A Rationale for Combination TherapeuticsSemantic proximity Read ↗

STING, the Endoplasmic Reticulum, and Mitochondria: Is Three a Crowd or a Conversation?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.