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Ionizing radiation triggers mitophagy to enhance DNA damage in cancer cells

28 Jul 2023

Abstract excerpt

Radiotherapy is an important cancer treatment strategy that causes DNA damage in tumor cells either directly or indirectly. Autophagy is a physiological process linked to DNA damage. Mitophagy is a form of autophagy, which specifically targets and eliminates impaired mitochondria, thereby upholding cellular homeostasis. However, the connection between DNA damage and mitophagy has yet to be fully elucidated. We...

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PMID: 37507394
DOI: 10.1038/s41420-023-01573-0

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