Article
Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation.
Redox biology - 1 Nov 2021
Kotla Sivareddy, Zhang Aijun, Imanishi Masaki, Ko Kyung Ae, Lin Steven H, Gi Young Jin, Moczygemba Margie, Isgandarova Sevinj, Schadler Keri L, Chung Caroline, Milgrom Sarah A, Banchs Jose, Yusuf Syed Wamique, Amaya Diana N, Guo Huifang, Thomas Tamlyn N, Shen Ying H, Deswal Anita, Herrmann Joerg, Kleinerman Eugenie S, Entman Mark L, Cooke John P, Schifitto Giovanni, Maggirwar Sanjay B, McBeath Elena, Gupte Anisha A, Krishnan Sunil, Patel Zarana S, Yoon Yisang, Burks Jared K, Fujiwara Keigi, Brookes Paul S, Le Nhat-Tu, Hamilton Dale J, Abe Jun-Ichi
Abstract excerpt
The incidence of cardiovascular disease (CVD) is higher in cancer survivors than in the general population. Several cancer treatments are recognized as risk factors for CVD, but specific therapies are unavailable. Many cancer treatments activate shared signaling events, which reprogram myeloid cells (MCs) towards persistent senescence-associated secretory phenotype (SASP) and consequently CVD, but the exact...
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