Article

MICROGLIAL CELL EXPRESSION OF THE TYPE 2 CANNABINOID RECEPTOR REGULATES IMMUNE-MEDIATED NEUROINFLAMMATION

2023-08-14

Abstract excerpt

<h4>ABSTRACT</h4> Neuroinflammation is a recognized complication of immunotherapeutic approaches such as immune checkpoint inhibitor treatment, chimeric antigen receptor therapy, and graft versus host disease (GVHD) occurring after allogeneic hematopoietic stem cell transplantation. While T cells and inflammatory cytokines play a role in this process, the precise interplay between the adaptive and innate arms of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 30441d28-5fdb-51a1-8493-4c3288a96e1b
DOI: 10.1101/2023.08.10.552854

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MICROGLIAL CELL EXPRESSION OF THE TYPE 2 CANNABINOID RECEPTOR REGULATES IMMUNE-MEDIATED NEUROINFLAMMATIONDOI 10.1101/2023.08.10.552854Read

Activation of central cannabinoid type 2 receptors, but not on peripheral immune cells, is required for endocannabinoid-mediated neuroprotection in Parkinson´s diseaseSemantic proximity Read

The CB2 receptor and its role as a regulator of inflammationSemantic proximity Read

Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and diseaseSemantic proximity Read

Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathySemantic proximity Read

Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cellsSemantic proximity Read

Orally bioavailable CB2 receptor agonists attenuate neuroinflammation and stabilize the blood–brain barrierSemantic proximity Read

Endocannabinoid Modulation of Microglial Phenotypes in NeuropathologySemantic proximity Read

Cannabinoid receptor expression in immune cells.Semantic proximity Read

Microglia activation states and cannabinoid system: Therapeutic implications.Semantic proximity Read

Adjuvant Cannabinoid Receptor Type 2 Agonist Modulates the Polarization of Microglia Towards a Non-Inflammatory Phenotype in Experimental Pneumococcal Meningitis.Semantic proximity Read

Expression and Functions of the CB2 Receptor in Human LeukocytesSemantic proximity Read

Interleukin-37 modulates microglial phenotype and inhibits inflammatory response via the MyD88/NF-κB pathway in Lipopolysaccharide-induced neuroinflammationSemantic proximity Read