Article

pH regulatory molecules in the tumour microenvironment : modulators of aggressiveness and immune profile of human hepatocellular carcinoma

2018-01-01

Abstract excerpt

Background: Hepatocellular carcinoma (HCC) arises in an inflammatory, hypoxic/acidic microenvironment that favours tumour progression and fosters immunosuppression. Tumour cells survive this hostile environment by over-expressing pH regulatory molecules such as carbonic anhydrase (CA) IX, XII and V-ATPase complex, but the relevance of these molecules in HCC is poorly defined. Aim: The aim of this stu...

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Literature Corpus work: 1f2b7825-af0c-5698-8569-aed79d1ff413
DOI: 10.21954/ou.ro.0000dab1

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